Organic Chemistry is at the heart of our operations. Identified hits from high-throughput screens seldom exhibit optimal characteristics in terms of potency, selectivity and biocompatibility, thus requiring iterative optimization by chemical synthesis and analog expansion. Importantly, this is a time-consuming and highly specialized process seldom accessible to most academic groups working in biology.
Our experienced team of senior medicinal and organic chemists have extensive experience of the development of bioactive small molecules from both the pharmaceutical industry and academic research environments. Our facilities at Karolinska Institutet and Umeå University house state-of-the-art laboratories for organic synthesis, purification and analysis.
CBCS can provide a wide range of chemistry services, irregardless if your project originates from an earlier performed screen at CBCS or if you have other needs for chemistry support. Some of the services we provide are computational chemistry & modelling, medicinal chemistry consultation, iterative chemical optimisation (“hit to probe”), physiochemical and pharmacokinetic profiling of compounds and target deconvolution.