The Compounds

The collection is organized into representative screening sets, spanning from chemically diverse sets to approved drugs and pharmacological tool compounds. Various focused sets, such as kinase-, GPCRs- and PPI-targeted compounds, are also available. The SLL primary screening set is designed for various bioassays, from exploring isolated targets and phenotypic cell-based assays to testing systems based on whole organisms such as parasites, zebrafish, and plants. The compounds have lead- to drug-like properties with respect to parameters such as molecular weight, hydrogen bond acceptors and donors, lipophilicity and polar surface area. Filters addressing reactivity, PAINs and aggregation issues have been applied to ensure tractable hit compounds. After obtaining hit compounds, follow-up materials are available for further validation and downstream profiling.

 

The EU OpenScreen collection

The EU-OPENSCREEN compound collections can be accessed and used in high-throughput screening assays at any of the EU-OPENSCREEN screening partner sites. In Sweden, CBCS KI and CBCS Umeå are associated sites. The collection is hosted at Compound Center, CBCS KI.

With its unique collections, you can explore the chemical space and target biology with Europe´s only open-access chemical biology infrastructure. The main library, the European Chemical Biology Library (ECBL), consists of about 100,000 compounds with unbiased chemical diversity, designed by five academic computational chemistry groups, to which a growing number of compounds collected from European chemists will be added over the next years.

Compound Center

The Compound Center provides access to SciLifeLab´s compound collection. The compounds can be readily available in assay-ready plates through acoustic nano-litre scale liquid dispensing, a unique asset for the Swedish academic community.

Compound Center and its STT3K-Kiwi store offer fully automated storage and retrieval of compounds organized in 96-tube racks. The STT3K-Kiwi store provides a capacity of 224,000 tubes. Each tube contains a compound in 10mM DMSO solution stored at - 20 °C under humidity control.

We have access to a fully automated Bravo pipetting system (Agilent) for high throughput delivery of compounds to screen or further nano dispensing. The facility manages the national acoustic dispensing centre with a Labcyte Echo 550 fully integrated with a Labcyte access station and an "on-the-side" Labcyte Echo 525. We offer open access to research groups after proper education.

The key elements of compound management include:

  1. The management, storage, and processing of solids and liquids.

  2. Compound delivery and interface with key customers.

  3. Performance of instruments and automation that support these operations.

  4. Analytical techniques used for quality assurance.

  5. Sample informatics, including registration and compound quality data.

Quality Control (QC) of Compounds

Maintaining high compound quality standards is paramount at the CBCS Compound Center. Rigorous Quality Control measures are implemented to ensure the reliability and integrity of the compounds provided to researchers. The Compound Center ensures that the compounds meet stringent quality criteria through comprehensive analysis and characterisation techniques, ensuring their suitability for subsequent experiments and investigations.

The Order Portal

Accessing the Compound Collection is convenient through the CBCS Compound Center's Order Portal. The portal is a user-friendly platform where researchers can browse and select compounds of interest. It streamlines the ordering process, allowing researchers to request the desired compounds for their experiments easily.

For more information, review our available services below or reach out to speak with us directly about your research needs.