Design - Make - Test - Analyze
The DMTA cycle is a fundamental iterative process in drug discovery and small molecule screening. CBCS supports researchers in designing new compounds or modifying existing ones to improve their activity and pharmacological properties. The newly synthesized compounds are subsequently tested in an appropriate biological assay, and their effect is evaluated. Based on the result, another round of synthesis is started to optimize the desired effect further.
A requirement for starting a DMTA cycle is to have an assay designed to measure the effect of the compounds. CBCS may also support the development of such an assay.
Hit Validation
Hit validation serves to confirm the biological activity of initial hits identified through high-throughput or virtual screening. CBCS offers a diverse range of assay platforms and expertise to verify the hits' potency, selectivity, and mode of action. By validating hits early on, researchers can focus on the most promising candidates, avoiding potential false positives and focusing on compounds with true therapeutic potential. CBCS plays a crucial role in hit validation by assisting researchers in evaluating and validating hits obtained from screening campaigns.
Structure-Activity Relationship (SAR) Studies
SAR studies explore the relationship between a compound's chemical structure and its biological activity. CBCS provides medicinal chemistry support, enabling researchers to systematically modify the molecular structure of hits. Through SAR studies, researchers can optimize the compound's activity, potency, and pharmacokinetic properties, enhancing its potential as a lead candidate for drug development. Through SAR studies, CBCS aids in establishing the relationship between the structure of a hit compound and its biological activity. This valuable information helps researchers optimize hit compounds and guide subsequent medicinal chemistry efforts.
Tool Synthesis
In addition to hit validation and optimization, CBCS offers tool synthesis services. Tools, such as probes and chemical probes, are essential for investigating the mode of action of compounds, target identification, and understanding biological mechanisms. CBCS assists researchers in the synthesis of these tools, providing access to specialized chemistry expertise and state-of-the-art facilities.
See what other services are vailable below or reach out to discuss your research with a CBCS representative today.
