All projects together with CBCS start with an informal meeting, web-based or at one of our facilities at Karolinska Institute or Umeå, to discuss the background and objectives of the project. After that we will guide you towards the next step in the process. CBCS works according to a collaborative research model based on mutual commitment from our group and the involved Investigator. Our collaborations range from limited consultations and open-access instrumentation, to complex full-scale projects spanning several years from start to finish. No service is too small and no challenge too great. Smaller projects and actions requiring only limited time and resources can usually be accommodated quickly and without a formal application review.
For more substantial projects, a formal application and peer-review process is implemented to ensure that resources are prioritized according to scientific excellence. Once CBCS has been familiarized with the project details, investigators are invited to submit a formal CBCS Project Application to our Project Review Committee (PRC) for review and allocation of resources. The Project Review Committee (PRC) meet twice every year to triage project applications submitted to CBCS during the past 6 months. Project applications are scored based on scientific excellence, novelty, technical feasibility and relevance. High priority projects are resourced with the necessary personnel and lower priority projects are considered if resources allow.
Small molecule discovery is costly and academic funding is precious, especially when embarking on new research. Thus, CBCS strives to make collaboration as cost-effective as possible. The vast majority of cost associated with personnel, facilities, equipment, and standard consumables is covered or heavily subsidized by CBCS funding. Collaborators are usually expected to cover direct costs of project-specific reagents and external studies performed. The largest contribution of the collaborator is the dedication is his/her expertise and internal resources dedicated to the collaboration.
Over the years CBCS has completed projects in collaboration with all major Universities in Sweden and our talented group has provided input to more than 400 research projects during the past 8 years of operation, resulting in high-impact publications, innovations, patents and spin-off endeavors. A full CBCS publication list can be found in the SciLifeLab publication database.
EU-OPENSCREEN, the European Infrastructure of Open Screening Platforms for Chemical Biology, is an ESFRI project aimed at integrating available small molecule screening facilities in Europe into a pan-European network. This collaboration will provide academic researchers and SMEs chemical resources for hit discovery and optimisation. EU Openscreen plans to provide a European common database for deposition of screening results and a central screening facility will make available a large diversity-based screening collection of small molecules.